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Dysregulation of BAs receptor and metabolite-mediated signaling axes is increasingly implicated in the pathogenesis of inflammatory bowel disease, bile acid malabsorption, diarrhea-predominant irritable bowel syndrome, colorectal cancervia DNA damage and Wnt/ -catenin pathway activationand systemic conditions such as obesity, non-alcoholic fatty liver disease, and sepsis-related intestinal injury
The expressions of each protein in colon tissues were captured by optical microscope (magnification, 200 for colon tissues)
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