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TXNDR1 expression is however relatively homogenous in HSCs and the myeloid lineage and in different AML subtypes
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The very low rate constants for direct, glutathione-independent dithiol-disulfide exchange reactions between glutaredoxins and roGFP2 or other protein(S 2 )/protein(SH) 2 couples (despite favorable thermodynamics) are a prerequisite and great advantage for reliable redox measurements in vivo
Moreover, theranostic liposomes, which co-deliver drugs and imaging agents, have been developed to enable simultaneous therapy and real-time monitoring [121]
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