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Weight regain after GLP-1 discontinuation is substantial: a post-STEP-1 extension study showed that 68% of weight loss was regained within one year of stopping semaglutide [11]
Rosenstock J, Del Prato S, Franco DR, Vazquez LA, Dai B, Weerakkody GJ, Fernandez LA, Rodriguez A, Bergman B
Tirzepatide adds a second target, the GIP receptor, activating a dual pathway that supports fat metabolism and insulin sensitivity on top of appetite reduction
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