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As a clinically used antidepressant with known pharmacological profiles and safety record, paroxetine offers a promising therapeutic strategy for OA that can be easily translated from bench side to clinics

Interestingly, many of these brain regions do not express Gipr or Glp1r 31,32 , suggesting that these are secondary downstream pathways that are activated indirectly by mGIPR-Ab/P3

One is retatrutide, an injectable drug Eli Lilly is developing thats a triple agonist, meaning that in addition to GLP-1 and GIP, it also targets glucagon

High glucose levels and Gs-coupled receptor stimulation synergistically triggered insulin and GLP-1 secretion

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