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After GLP-1(11-37) fragments are prepared by the method through synthesis and biological fermentation, the N-terminal amino group and the hydroxyl groups of Ser, Thr and Tyr side chains are not protected, and the fragments directly react with OSu ester of the side chains, so that multi-site reaction is easily caused, a large amount of unexpected impurities are formed, the method is not beneficial to later separation and purification, and the yield is lower

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[11] These findings are relevant to cellular repair biology, but they should remain limited to experimental model interpretation