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Participants in these trials said they not only saw a reduction in weight but also improvements in metabolic markers and overall well-being
Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling
Critically, MC1R activation specifically drives eumelanin production, the darker and UV-absorbing form of melanin known to provides photoprotection
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