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Most Common Side Effects: Just like other GLP-1 medications, gastrointestinal issues were the most common: Nausea (especially during dose increases) Diarrhea Vomiting Constipation Abdominal pain The frequency: Higher with 8 mg and 12 mg doses compared to lower doses
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The rationale is that extended mid-ladder dwell time improves long-term tolerability and reduces dropout at the 8 to 12 mg transition [1][3]
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