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The JAMA Internal Medicine meta-analysis of 76 randomized trials quantified the class-wide risk: Cholelithiasis: relative risk 1.27 across all GLP-1 RAs Cholecystitis: relative risk 1.36 Biliary disease composite: relative risk 1.55 Higher doses carried higher risk than lower doses Longer treatment duration carried higher risk than shorter duration For high-risk populations, particularly older women, close monitoring for cholecystitis and cholelithiasis during GLP-1 therapy is recommended
Practical & safety How many doses are in a vial
Chen S, Yin L, Xu Z, An FM, Liu AR, Wang Y, et al
The insulin resistance paradox This is the primary safety concern, and it deserves detailed explanation
They may also reduce appetite and food intake, which can help to support weight loss
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