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Additional receptor destinations involve retrograde transport towards the Golgi apparatus ( Evidence from primary mouse islets and clonal beta cells (INS-1 832/3) shows that Exenatide causes a greater amount of GLP-1R degradation compared to endogenous GLP-1, with this effect apparently due to differences in the susceptibility of the agonists for degradation by the endopeptidase endothelin converting enzyme 1 (ECE1) (Metzler et al., 2001) is associated with the control of GLP-1R function

Unlike hormone replacement therapies, PT-141 doesn't affect hormone levels directly

Additionally, pack extra doses and needles in case of travel delays, as it may be difficult to get a replacement prescription abroad

PubMed Chang CH, et al

Prescriptions are valid for one year with physician approval