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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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Fe 2+ and Cu + react with H 2 O 2 , which is a product produced by the dismutation of the O 2 via SOD, to form extremely reactive OH (Eq

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L-glutamine should also be positioned carefully

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