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Updating this guidance to include advice on Mounjaro reignited discussions amongst the authors about using these drugs in people with existing retinopathy

"Anything that is going to produce robust weight loss," Apovian says, "there's going to be a percentage of that that's muscle." Reports suggest that GLP-1 treatments may cause between 25 to 40 percent loss of lean mass, which includes muscle massalthough more studies are needed to understand how this affects strength

Getting the practical aspects of tirzepatide administration right reduces anxiety, ensures accurate dosing, and eliminates avoidable triggers

Many patients tolerate both medications well concurrently