MC4R activation also modulates noradrenergic and serotoninergic neurotransmission, reflecting the multi-neurotransmitter landscape of hypothalamic sexual behaviour regulation
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The figure shows robust expression of ZO-1 in epithelial enterocytes of small intestinal organoids (which is diminished under CARD9-inhibited conditions)
That finding is what positions PDRN as a candidate for melasma protocols in addition to standard rejuvenation work