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Pollyanna Pitt
A separate study following participants from the STEP 1 clinical trial found that weight, waist circumference and cardiometabolic risk factors largely returned toward baseline levels within 12 months of stopping the medication
Also, while the manufacturers of metformin recommend against breastfeeding while taking the drug, data have shown that metformin is excreted into breast milk in small amounts and adverse effects on infant plasma glucose have not been reported in human studies
Proactive education, slow dose increases, lifestyle changes, and early use of supportive treatments can prevent symptoms from becoming severe
These effects are downstream of better sleep and improved metabolic function rather than a direct neurological effect of the peptide, which makes them durable rather than temporary
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