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2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin
IGF-1 levels, the most reliable blood marker of growth hormone activity, typically rise 15 to 25% above baseline within 8 to 12 weeks of consistent nightly dosing (Walker, Clin Interv Aging, 2006)
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