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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

Retatrutide addresses the first challenge exceptionally well through caloric reduction and metabolic enhancement

Xiaojun M, Min S, Yushan Y, Gaofei R, Jingwen H, Guijun Q

Unlike Januvia's once-a-day oral dosing schedule, Byetta needs subcutaneous injections twice daily before meals

However, they are anecdotal claims that cannot be supported by clinical evidence