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activates GLP-1 receptors in hypothalamic appetite centres Reduces hunger, caloric intake, and body weight independent of glycaemic effect Contributes to the 24 kg average weight loss observed with Rybelsus 7mg/14mg in PIONEER trials ORAL DELIVERY TECHNOLOGY SALCAPROZATE SODIUM (SNAC): Semaglutide is normally degraded by gastric proteases and poorly absorbed orally Rybelsus uses SNAC (sodium N-(8-[2-hydroxybenzoyl] amino) caprylate) as an absorption enhancer SNAC buffers the local gastric pH around the tablet, protects semaglutide from enzymatic degradation, and transiently enhances its transcellular absorption through the gastric mucosa Oral bioavailability: ~1% (compared to near-100% for injectable semaglutide) hence high drug load and strict fasting administration requirement Faq for medicine: 1.What is Rybelsus 3mg used for in type 2 diabetes management

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