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Urea makes up about 7% of NMFs next to other things such as amino acids (40%), PCA (12%) or Lactate (12%)
CI, confidence interval
The absence of a consistently reported severe acute toxicological signal in published rodent model contexts is reassuring only within the tested models, study durations, exposure conditions, animal characteristics, and reported endpoints
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To investigate the severe liver damage and increased mortality observed in hepsin / mice during the early stages after APAP administration, we employed ultra-performance liquid chromatography-tandem mass spectrometry to measure levels of APAP-cysteine adducts in mouse liver tissue, which indirectly assesses the generation of the toxic APAP metabolite, NAPQI (Hairin et al
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