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Use within 28-30 days when stored at 2-8 C

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Similar relative bioavailability of icodec was shown for IcoSema dosing versus icodec dosing alone, as the 90% CI for the ratio of total icodec exposure after single dose (AUC 0 t ,SD,Icodec ) between IcoSema and icodec alone was fully contained within the bioequivalence acceptance interval of [0.80;1.25]

When gut bacteria ferment fibre in the colon, they produce short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate, which directly stimulate GLP-1 release from intestinal L-cells

This discovery still needs to be confirmed in humans, the researchers note