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"We discovered that patients are saying 'I used to not go to the gym because I was so overweight and felt very self-conscious, but after GLP-1s I kind of got to a place where I didn't feel embarrassed going to the gym,'" Pye said

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Importantly, the mere presence of PanIN lesions is not necessarily problematic, as low-grade PanINs are present in 50-80% of adults and do not universally transform into malignancy 21

However, as people enter middle age, the rewards of their fitness efforts become increasingly limited

The exact escalation pace depends on your tolerability and response