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The medication's weight loss effects are primarily driven by appetite suppression through central nervous system effects, with the gastric emptying delay contributing to early satiety

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In contrast to earlier GLP-1 receptor agonists, which primarily target appetite suppression and glycemic improvement, Retatrutide leverages GCG receptor activation to stimulate lipolysis and elevate basal metabolic rate, thereby contributing to a more pronounced and sustained reduction in adiposity as observed in research models

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For many people, these side effects are reduced over time and should not be severe

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