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Allergy to any of the products ingredients Pregnancy or breastfeeding Liver or kidney disease When under close medical supervision at hospital Active cancer/undergoing chemotherapy or radiotherapy Prone to keloid scarring DO NOT BOOK A B12 INJECTION IF ANY OF THESE APPLY TO YOU, UNLESS YOU HAVE EXPRESS PERMISSION FROM YOUR GP IN WHICH CASE PLEASE FULLY INFORM ME BEFORE THANKYOU

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The estimand concept [3] provides a framework to align trial design and objectives to ensure that the estimated treatment effect is relevant to the scientific question(s) of interest