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Human safety is not established because large human trials have not been completed
Over time, the elastic fibers become damaged and the collagen network remodels to fit the larger shape
It incorporates key modifications, including 14E/17R mutations to stabilize an -helical segment via a salt bridge, multiple proline substitutions (25P, 28P, 29P) to reduce -sheet formation, and N-terminal C20 fatty diacid lipidation for reversible albumin binding (Kruse et al
de Jong M, van der Worp HB, van der Graaf Y, Visseren FLJ, Westerink J
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