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In one of the trials for diazepam rectal gel, two or three doses of diazepam rectal gel (based on age) were administered, with the second dose 4 h after the first dose and, for adults, another at 12 h in order to maintain plasma levels of diazepam (150300 ng/mL) [24], which contributed to the FDA label requirements of 4 h between first and second doses of diazepam nasal spray [57]
In 2018, the Farm Bill was enacted at the federal level and redefined marijuana and hemp
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