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Insulin resistance severity and pancreatic beta-cell function contribute to individual variability in response
* The AAFP has reviewed this course and deemed it acceptable for up to 5.00 Enduring Materials, Self-Study AAFP Prescribed credit(s )
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You should avoid this combination if you: Have liver disease or take medications processed by CYP450 enzymes Are pregnant, breastfeeding, or under 18 safety data is lacking Have a sensitive digestive system and dont tolerate GI side effects well Already take metformin or other insulin-sensitizing drugs, as stacking may be redundant or risky If any of these apply to you, consult a healthcare provider before adding berberine or consider safer, more studied alternatives
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