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No organ toxicity, no carcinogenicity signals, no reproductive toxicity have been demonstrated in animal models to date
Each drug has a prescribed loading dose to begin the first four weeks
Semaglutide is a GLP-1 receptor agonist that mimics the behavior of the GLP-1 hormone, which is naturally released after eating
Though these agents do increase arousal threshold in OSA with a modest improvement OSA severity [86, 87], they may have the potential for neurological depression and worsening of hypoxemia associated with OSA at higher doses
Sikiric et al., 2006
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