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Serotonergic symptoms to report immediately : new-onset tremor in the hands or jaw, jerking movements (myoclonus) during sleep or waking, profuse sweating not explained by exercise or ambient temperature, unexplained diarrhea (three or more loose stools per day), and any episode of confusion or agitation

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An in vitro model composed of senescent Leydig cells was used

However, while anecdotal reports suggest potential benefits of coffee enemas, scientific evidence to support these claims remains limited