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Prescriptions with an RxNorm code corresponding to the pharmacologic or ingredient name only (e.g., tirzepatide, semaglutide) were excluded
Polymorphisms of SHMT, TYMS , and DHFR have been investigated only in one case-control study each (Copped et al., 2009
Continue prescribed nutrition and physical activity strategies, and dont make supplement or medication changes without provider input
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means that it works by mimicking the effects of GLP-1, a hormone produced in the gut that stimulates insulin secretion, reduces glucagon secretion, and slows down gastric emptying
GLP-1 effects are mediated through binding to the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR) that signals primarily through the stimulatory G protein G s
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