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Andrew Kraftson, MD, the director of the weight navigation program at Michigan Medicine in Ann Arbor, agrees that skipping a single dose is unlikely to quickly alleviate any gastrointestinal side effects

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True irritation requiring product discontinuation presents as persistent burning or stinging lasting beyond application period, significant redness spreading beyond application zone or lasting multiple hours, swelling of eyelids or periorbital area, increased sensitivity making area uncomfortable to touch, or itching suggesting allergic response

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Carro E, Trejo JL, Busiguina S, Torres-Aleman I