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Four small molecules [sulfamethoxazole, ketoprofen, MES (4- morpholineethanesulfonic acid), glyphosate], and 4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) were used for the spiking sample, and Acetyl-d3-L-carnitine hydrochloride used as the internal standard in selected reaction monitoring (SRM) analysis was purchased from Sigma-Aldrich (St

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Clinical trial data show that gastrointestinal adverse effectsincluding nausea, vomiting, diarrhea, and abdominal discomfortoccur in 20-50% of patients initiating GLP-1 therapy, with rates varying by specific agent and dose

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