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Trypsin activation converted the latent jr PPO1-wt to a pre-active form as the cleavage sites (Arg348-Val349, Lys350-Lys351 and Lys354-Ala355) are located within the linker region (Pro336-Pro375, Fig

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(3) M Bex, R Abs, D Maiter, et al (2002) The effects of growth hormone replacement therapy on bone metabolism in adult-onset growth hormone deficiency: a 2-year open randomized controlled multicenter trial Journal of Bone Mineral Research, 2002 Jun, Volume 17 (Issue 6), Pages 1081-94

The right lifestyle habits such as stress reduction, physical activity along with limited alcohol or sugar intake can optimize growth hormone balance