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There is also reciprocal activation of factor XII by kallikrein resulting in amplification of the system

Antioxidants 13(5):606

These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, as well as exogenous sources, including radiation, pollution, and smoking

In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways

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