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A well-matched population was found in the GLP-1RAs vs metformin groups ( n =47,097 each) after PSM (ESM Figs 2 and 3)

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The peptide itself is only one part of the equation

In osteoarthritis (OA), research has also demonstrated that IgE-mediated mast cells can be activated via FcRI and Syk, leading to mast cell degranulation and the release of pro-inflammatory factors and cartilage-degrading mediators (including tryptase), resulting in cartilage and joint destruction and aggravating OA cartilage damage (132)