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How Semaglutide May Contribute to Palpitations Semaglutide affects the body in several ways that could lead to heart palpitations: Changes in Blood Sugar This medication lowers blood sugar levels, which can sometimes cause hypoglycemia (low blood sugar)
Clinical data suggests 1530% of patients may require dose adjustment or protocol modification within the first 36 months
Second, preclinical enthusiasm outpaces clinical confirmation
Notably, Orforglipron (EC 50 1.2 nM), a pyrazolopyridine derivative that acts as a biased partial agonist and is administered orally once daily, has entered Phase III clinical trial (NCT3502970)
Cancer 18 , 549561 (2018)
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