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[Lincoff SELECT, NEJM 2023] FLOW Trial (NEJM 2024)

All of the above strategies improve insulin sensitivity, creating a positive feedback loop where better insulin sensitivity further reduces VLDL production

Mutations in the AGXT2 gene are associated with benign -aminoisobutyric aciduria

Altintas Dogan et al 75 experiment found that liraglutide significantly reduced body weight, decreased inflammatory markers such as IL-6 and MCP-1, increased exertional spirometry (FVC) and carbon monoxide diffusion capacity, and improved COPD assessment test scores, but no significant improvement in FEV1, FEV1/FVC, or 6-minute walk tests, suggesting the possibility that GLP-1RA may reduce inflammatory responses, improve lung function, and mitigate the degree of impaired health in patients with COPD

It's unique to retatrutide because no other approved obesity medication activates glucagon receptors