An inherited disorder of the cellular uptake and trafficking of vitamin B2 metabolites may result in poor intestinal absorption, increased urinary loss, and disrupted homeostasis of vitamin B2 metabolites in the CNS
Transl Neurodegener 13(1):37 Pisani V, Stefani A, Pierantozzi M, Natoli S, Stanzione P, Franciotta D et al (2012) Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinsons disease
(2015), the His115Leu mutation in bifunctional riboflavin kinase/FMN adenylyltransferase reduced enzyme activity to 55%, which was a probable reason for riboflavin accumulation in E
Genetic screening is advisable before initiation in at-risk populations
Most patients feel reduced appetite and a noticeable increase in energy on the same day they take their first dose typically within a few hours of ingestion