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Supplements like berberine or curcumin are marketed as ways to boost your body's natural GLP-1 production or mimic its effects, but the reality is that the data behind these claims is limited." This isn't to say that some supplements don't offer any potential benefits

They suppress appetite, slow gastric emptying (how quickly food leaves your stomach), enhance insulin release when sugar is present, reduce glucagon (a hormone that raises blood sugar), and produce significant weight loss and better blood sugar control in clinical trials

Large Meals : Overeating or consuming large portions can negate the appetite-suppressing effects of GLP-1 drugs, leading to discomfort and slower progress toward your goal body weight

For type 2 diabetes, the American Diabetes Association estimates $12,022 per person per year in medical expenditure attributable to the disease

Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, et al