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Maximum: 20 mg daily Extended release Initial: 2.55 mg once daily with first main meal Maximum: 20 mg daily Glimepiride (Amaryl) Dosage Initial: 12 mg once daily with first main meal Maximum: 8 mg daily Possible side effects include: Hypoglycemia Weight gain Meglitinides (glinides) Primary mechanism(s) of action Meglitinides stimulate insulin release by pancreatic beta cells

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To assess the efficacy of combination treatment, tumour-bearing mice were treated as above with 5FU + metformin and CC3-quantified, showing an increase in average cell death per tumour per mouse with combination treatment (Extended Data Fig