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Hydroxyl radicals are formed due to the redox cycling of Fe 2+ via Fenton reaction, where iron reacts with H 2 O 2 to produce hydroxyl radical
Modulation of serum brain-derived neurotrophic factor by a single dose of ayahuasca: observation from a randomized controlled trial
Additionally, among SASP factors, there are growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor 1 (IGF-1), which, when secreted into the environment by senescence cells, stimulate the repair and regeneration of surrounding tissues [13]
Important Note on the Evidence Base Important note on the evidence base: The clinical evidence on the IGF-1 axis derives largely from trials of recombinant human IGF-1 (rhIGF-1, sold as mecasermin / Increlex), which is FDA-approved for severe primary IGF-1 deficiency in pediatric patients
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