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Bydureon)] was synthesized by encapsulating exenatide into microspheres of medical-grade poly-( D , L -lactide-co-glycolide) which enables the drug to be released over an extended period of time (DeYoung et al., The efficacy of once-weekly ER (2 mg) was compared to that of once-daily liraglutide (1.8 mg) in a 26-week trial in T2DM patients (Buse et al., DPP-4 inhibitors The DPP-4 inhibitors mediate their action by inhibiting the enzyme DPP-4, which prevents the breakdown of GLP-1 and thereby increases endogenous GLP-1 levels
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