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For individuals significantly above 250 pounds, extended protocols of 16-20 weeks rather than higher daily doses often produce better outcomes

If you have an underlying health condition like kidney disease, or if you take medication that interferes with B6 metabolism or absorption (such as oral contraceptives, hypertension drugs like hydralazine, and others), ask your doctor about appropriate supplement dosing

Because MOTS-c involves only 4 injections per cycle, rotate to a different quadrant of the abdomen with each dose to minimize localized tissue irritation

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However, initiation of desensitization is not recommended during pregnancy