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The binding interaction analysis compounds 86 , 8HP (co-crystallized ligand), and DSR-141562 (standard) showed that all ligands occupied the P-clamp and interacted with key hydrophobic residues L388, F392, and F424
But when the discs start deteriorating, pain sets in, signaled by neurons in the area
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Start low and recheck labs or symptoms early
This transition is reinforced by a SOX2JAKSTAT feedback loop, which sustains chromatin accessibility and resistance to AR-targeted therapies such as enzalutamide
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