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Reference: Pickart L, Vasquez-Soltero JM, Margolina A

The research basethough extensive, comprising over 100 published studiesis entirely preclinical (animal models and in vitro experiments)

However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics

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Our data show that in mice intestinal barrier function is impaired before the clinical onset of arthritis, while in humans serum markers associated with impaired intestinal barrier function are also increased before the onset of RA and associated with a higher risk to develop RA later on