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Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease Nature Medicine Phase 2a trial demonstrated retatrutide 12 mg achieved 82.4% mean reduction in liver fat at 24 weeks, with 86% of participants normalizing liver fat levels below 5%
It also increased levels of Faecalibacterium prausnitzii, a key butyrate-producing bacterium with anti-inflammatory properties
Side effect management by dose level Side effects from retatrutide are dose-dependent and predictable
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Clinical trial participants who maintained protein intake above 90g daily during Retatrutide treatment showed significantly better lean mass retention than those who let protein intake decline with overall appetite
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