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Retatrutide is an investigational GLP-1, GIP, and glucagon triple receptor agonist currently in Phase 3 trials

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The medication begins by helping control appetite, slowing digestion, and balancing blood sugar

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Additional genetic factors like FTO rs9939609 and MC4R rs17782313 affect appetite regulation and fat storage, helping explain why some patients lose weight faster than others on the same semaglutide dose

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Energy levels and daily activities can usually be maintained normally during your first week on GLP-1 therapy

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