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The results indicated that in mice on the diet supplemented with cholestyramine, which depletes bile acids, APAP toxicity was exacerbated, whereas those on a diet supplemented with cholic acid had a more rapid recovery from APAP

Since dimercaprol also readily chelates copper, it is used in the treatment of Wilsons disease, a hereditary disease in which excess copper is accumulated in the body (Leggio et al., 2005)

Genetic and pharmacologic NNMT suppression reduces adiposity and improves metabolic readouts in preclinical models, with supportive cellular data showing increases in NAD and SAM and suppression of lipogenesis

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33 DingN.WangA.ZhangX.WuY.WangR.CuiH.et al (2017)