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They work by blocking an enzyme called tyrosinase, which is involved in producing melanin (the pigment responsible for skin color)
Measurable in Vivo Flux: In rats, ACE inhibition with captopril raised plasma Ac-SDKP from 3.1 0.2 to 15.1 0.7 nmol/L, an increase blocked by the meprin- inhibitor actinonin demonstrating continuous T4-to-Ac-SDKP conversion in vivo (PMID 26962108)
High-performance liquid chromatography
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Expert Opinion on Biological Therapy (2012) 11
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