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It is particularly common in individuals with certain risk factors, including those who have undergone gastric or small intestine resections, have inflammatory bowel disease, use metformin or proton pump inhibitors, follow a vegan diet, or are older than 75 years

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A study examining MCL healing in rats found that BPC-157-treated animals demonstrated enhanced ligament tensile strength and improved histological organization compared to controls, with the same VEGF-mediated angiogenic and fibroblast-stimulating mechanisms operative in ligament tissue as in tendon