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The most studied and controversial target is SLC3A2, which can mediate the export of spermidine, spermine, and putrescine in colonic epithelial cells, as well as the extracellular release of the polyamine metabolic intermediate N1-acetylspermidine in liver cancer cells [290, 291]
doi: 10.1016/j.cmet.2013.01.003 90 CaniPDBibiloniRKnaufCWagetANeyrinckAMDelzenneNMet al
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Many of the proposed benefits are extrapolated from rodent studies, and the long-term effects in humans remain largely unknown [5]
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