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A 2001 RCT by Nusgens and colleagues published in the Journal of Investigative Dermatology (N=33) used punch biopsy to demonstrate that topical vitamin C significantly increases mRNA levels of collagen I, collagen III, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the human dermis direct molecular evidence of collagen gene upregulation at the tissue level

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It is also utilized in gastrointestinal repair