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Sources NIH Office of Dietary Supplements, Vitamin B12 Fact Sheet NIH Office of Dietary Supplements, Choline Fact Sheet MedlinePlus, Cyanocobalamin Injection Mayo Clinic, Vitamin B12 Injections and Weight Loss NCBI Bookshelf, Essential Amino Acids PubMed, Inositol Phosphate Signaling Network The American Journal of Clinical Nutrition, Lipotropic Agents and Lipid Transport

Common initial side effects include nausea, vomiting, diarrhea, and constipation during the first 2-4 weeks

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This suggests that NP4 could effectively promote the polarization of M2-type macrophages towards M1-type macrophages, thereby alleviating immune suppression

The study included 17,604 people who were at least 45 years old and had a body mass index greater than or equal to 27